谢晓亮

中国科学院院士、美国科学院外籍院士、第十四届全国政协常委、生物物理化学家、北京大学李兆基讲席教授
谢晓亮(Xiaoliang Sunney Xie),男,汉族,1962年出生于中国北京,无党派人士中国科学院院士、美国科学院外籍院士 ,生物物理化学家,曾任哈佛大学化学与化学生物系终身教授、Mallinckrodt讲席教授 ,北京大学李兆基讲席教授北京大学理学部主任 ,北京昌平实验室主任,第十四届全国政协委员、常委、教科卫体委员会委员
谢晓亮于1980年考入北京大学化学系;1990年从加州大学圣地亚哥分校博士毕业后进入芝加哥大学从事博士后研究;1992年进入美国太平洋西北国家实验室工作;1999年被聘为哈佛大学化学与化学生物系终身教授,是改革开放后哈佛大学引进的第一位来自中国大陆的终身教授;2009年担任哈佛大学Mallinckrodt讲席教授;2010年主持创办北京大学生物动态光学成像中心,担任主任;2016年组建北京大学未来基因诊断高精尖创新中心,担任主任;2017年当选为中国科学院外籍院士;2018年7月全职回到北京大学工作,并担任北京大学生物医学前沿创新中心主任;2020年担任北京昌平实验室主任;2023年6月由中国科学院外籍院士转为中国科学院院士。
谢晓亮的主要研究方向包含:基础研究、技术开发和医学研究三个领域。基础研究:单分子酶学、单分子生物物理化学、基因表达和调控、表观遗传学、细胞分化和重编程机理、基因组不稳定性;技术发展:单分子成像、单细胞基因组学、相干拉曼散射显微成像、DNA测序;医学研究:体外受精胚胎植入前遗传学筛查与诊断、早期癌症诊断 ,新冠中和抗体药物研发

人物经历

1962年6月,谢晓亮出生于北京,并在北京大学附属小学北京大学附属中学度过小学与中学阶段
1980年,考入北京大学化学系,业余时间还旁听了物理系和数学系的课程,还利用暑假到实验室做实验,学有机合成,又写计算机程序做化学计算。
1985年夏,赴加州大学圣地亚哥分校攻读博士,师从研究超快激光研究化学动力学的约翰·西蒙(John Simon)。
1989年,博士毕业后去芝加哥大学物理化学教授格雷厄姆·弗莱明(Graham Fleming)的实验室做博士后。
1992年,进入美国太平洋西北国家实验室(PNNL)工作,从事单个分子光谱和动力学、超高分辨光学成像研究,是PNNL自1965年成立以来第一位来自中国大陆的科学家。
1999年,被聘为哈佛大学化学与化学生物系终身教授,是改革开放以后哈佛大学引进的第一位来自中国大陆的终身教授。
2000年,在哈佛大学的第一年,谢晓亮写了6个申请书,全部获得资助。
2001年9月7日,受聘北京大学化学学院客座教授,同一天,受聘为分子动态与稳态结构国家重点实验室学术委员会委员。
2004年,获得美国国立卫生研究院(NIH)先锋奖,在之后五年中每年获得50万美元的自由支配经费
2008年,被北京大学生命科学学院聘为讲座教授;同年,当选为美国艺术与科学学院院士。
2009年,担任哈佛大学Mallinckrodt讲席教授,是改革开放后大陆学者获得哈佛大学冠名讲席教授的第一人。
2010年12月,在北京大学主持创办了北京大学生物动态光学成像中心(BIOPIC),担任主任。
2011年,当选为美国国家科学院院士。
2013年,第二次获得美国国立卫生研究院(NIH)先锋奖
2015年,谢晓亮与斯坦福大学教授Karl Deisseroth共同获得阿尔伯尼生物医学奖,成为该奖项的首位华人获得者;同年,获得美国化学会德拜奖
2016年,组建了北京未来基因诊断高精尖创新中心(ICG),担任主任;10月17日,当选为美国国家医学院院士
2017年9月16日,获得求是杰出科学家奖 ;11月,当选中国科学院外籍院士
2018年7月,正式全职回到北京大学工作,担任北京大学李兆基讲席教授;同年担任主任的北京大学生物动态光学成像中心,更名为“北京大学生物医学前沿创新中心”(Biomedical Pioneering Innovation Center,BIOPIC)
2019年11月,担任北京大学理学部主任
2020年10月,担任北京昌平实验室主任
2023年6月,由中国科学院外籍院士转为中国科学院院士。

主要成就

科研成就

  • 科研综述
谢晓亮是单分子酶学的创始人、单分子生物物理化学的奠基人之一、相干拉曼散射显微成像技术和单细胞基因组学的开拓者。谢晓亮作为单分子生物物理化学家,他勇于突破学科界限,从物理化学、生物物理到生物化学,再到分子生物学、基因组学及临床医学,无畏探索,不断创新,在相关新兴交叉学科做出了创造性贡献。
谢晓亮不仅是生物物理化学基础科学研究的国际领军人物,近年来大力推动了无标记光学成像技术和新型单细胞基因组测序技术在医学中的应用。2012年谢晓亮在单细胞全基因组学研究有了突破性进展,开发了单细胞全基因组均匀扩增的新方法—多重退火循环扩增法(MALBAC)。2014年9月19日,世界上第一例“MALBAC婴儿”在北医三院诞生,标志着中国胚胎植入前遗传诊断技术处于世界领先水平
在抗击新冠疫情过程中,谢晓亮团队成功研制出一组针对所有新冠病毒变种的广谱中和抗体药物SA55/SA58,并已将其授权转让给科兴生物公司
  • 研究领域
谢晓亮课题组的研究方向包含基础科学研究领域、技术研究领域和医学研究领域三个领域
领域
说明
基础研究
单分子酶学、单分子生物物理化学、基因表达和调控、表观遗传学、细胞分化和重编程机理、基因组不稳定性
技术发展
单分子成像、单细胞基因组学、相干拉曼散射显微成像、DNA 测序
医学研究
体外受精胚胎植入前遗传学筛查与诊断、早期癌症诊断
  • 学术论著
截至2023年1月,谢晓亮共发表SCI收录科学论文240余篇 [3]
Single Molecule Spectroscopy and Imaging
Xie, X. Sunney; Dunn, Robert C. "Probing Single Molecule Dynamics" Science 265: 361-364 (1994).
Sánchez, Erik J; Novotny, Lukas; Xie, X. Sunney. "Near-field Fluorescence Microscopy Based on Two-photon Excitation with Metal Tips" Phys Rev Lett 82: 4014-4017 (1999).
Min, Wei; Lu, Sijia; Chong, Shasha; Roy, Rahul; Holtom, Gary R.; Xie, X. Sunney. "Imaging Chromophores with Undetectable Fluorescence by Stimulated Emission Microscopy" Nature 461: 1105-1109 (2009).
Chong, Shasha; Min, Wei; Xie, X. Sunney. "Ground-State Depletion Microscopy: Detection Sensitivity of Single-Molecule Optical Absorption at Room Temperature" J Phys Chem Lett 1:3316-3322 (2010).
Zhou, Yuexin; Wang, Ping; Tang, Feng; Gao, Ge; Huang, Lei; Wei, Wensheng; Xie, X. Sunney “Painting a specific chromosome with CRISPR/Cas9 for live-cell imaging”, Cell Research, doi:10.1038/cr.2017.9 (2017).
Single Molecule Enzymology
Lu, H. Peter; Xun, Luying; Xie, X. Sunney. "Single-Molecule Enzymatic Dynamics" Science 282: 1877-1882 (1998).
Yang, Haw; Luo, Guobin; Karnchanaphanurach, Pallop; Louie, Tai-Man; Rech, Ivan; Cova, Sergio; Xun, Luying; Xie, X. Sunney. "Protein Conformational Dynamics Probed by Single-Molecule Electron Transfer" Science 302: 262-266 (2003).
Min, Wei; Luo, Guobin; Cherayil, Binny J.; Kou, S. C.; Xie, X. Sunney. "Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule" Phys Rev Lett 94: 198302(1-4) (2005).
English, Brian P.; Min, Wei; van Oijen, Antoine M.; Lee, Kang Taek; Luo, Guobin; Sun, Hongye; Cherayil, Binny J.; Kou, S.C.; Xie, X. Sunney. "Ever-Fluctuating Single Enzyme Molecules: Michaelis-Menten Equation Revisited" Nat Chem Bio 2: 87-94 (2006).
Blainey, Paul C.; Luo, Guobin; Ko9u, S.C.; Mangel, Walter F.; Verdine, Gregory L.; Bagchi, Biman; Xie, X. Sunney. "Nonspecifically Bound Proteins Spin While Diffusing Along DNA" Nat Struct Mol Biol 16: 1224-1229 (2009).
Kim, Sangjin; Brostr?mer, Erik, Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao, Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yiqin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney. “Probing Allostery Through DNA” Science 339: 816-819 (2013).
Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).
Gene Expression and Regulation
Yu, Ji; Xiao, Jie; Ren, Xiaojia; Lao, Kaiqin; Xie, X. Sunney. "Probing Gene Expression in Live Cells, One Protein Molecule at a Time" Science 311: 1600-1603 (2006).
Cai, Long; Friedman, Nir; Xie, X. Sunney. "Stochastic Protein Expression in Individual Cells at the Single Molecule Level" Nature 440: 358-362 (2006).
Elf, Johan; Li, Gene-Wei; Xie, X. Sunney. "Probing Transcription Factor Dynamics at the Single-Molecule Level in a Living Cell" Science 316: 1191-1194 (2007).
Choi, Paul J.; Cai, Long; Frieda, Kirsten; Xie, X. Sunney. "A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell" Science 322: 442-446 (2008).
Taniguchi, Yuichi; Choi, Paul J.; Li, Gene-Wei; Chen, Huiyi; Babu, Mohan; Hearn, Jeremy; Emili, Andrew; Xie, X. Sunney. "Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells" Science 329: 533-538 (2010).
Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria" Cell 158: 314-326 (2014).
Ge, Hao; Qian, Hong; and Xie, X. Sunney. "Stochastic Phenotype Transition of a Single Cell in an Intermediate Region of Gene State Switching" Phys Rev Lett 114(7) (2015).
Coherent Raman Microscopy
Zumbusch, Andreas; Holtom, Gary R.; Xie, X. Sunney. “Vibrational Microscopy Using Coherent Anti-Stokes Raman Scattering" Phys Rev Lett 82: 4142-4145 (1999).
Evans, Conor L.; Potma, Eric O.; Puoris'haag, Mehron; C?té, Daniel; Lin, Charles P.; Xie, X. Sunney. "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy" Proc Nat. Aca Sci 102: 16807-16812 (2005).
Freudiger, Christian W.; Min, Wei; Saar, Brian G.; Lu, Sijia; Holtom, Gary R.; He, Chengwei; Tsai, Jason C.; Kang, Jing X.; Xie, X. Sunney. "Label-Free Biomedical Imaging with High sensitivity by Stimulated Raman Scattering Microscopy" Science 322:1857-1860 (2008).
Saar, Brian G.; Freudiger, Christian W.; Reichman, Jay; Stanley, C. Michael; Holtom, Gary R.; Xie, X. Sunney. "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering" Science 330: 1368-1370 (2010).
Wang, Meng C.; Min, Wei; Freudiger, Christian W.; Ruvkun, Gary; Xie, X. Sunney. "RNAi Screening for Fat Regulatory Genes with SRS Microscopy" Nat Methods 8: 135-138 (2011).
Fu, Dan; Zhou, Jing; Zhu, Wenjing Suzanne; Manley, Paul W.; Wang, Y. Karen; Hood, Tami; Wylie, Andrew; Xie, X. Sunney. "Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering" Nat Chem 6: 614-622 (2014).
Single Cell Genomics
Zong, Chenghang; Lu, Sijia; Chapman, Alec R.; Xie, X. Sunney. "Genome-Wide Detection of Single-Nucleotide and Copy-Number Variations of a Single Human Cell" Science 338: 1622-1626 (2012).
Lu, Sijia; Zong, Chenghang; Fan, Wei; Yang, Mingyu; Li, Jinsen; Chapman, Alec R.; Zhu, Ping; Hu, Xuesong; Xu, Liya; Bai, Fan; Qiao, Jie; Tang, Fuchou; Li, Ruiqiang; Xie, X. Sunney. "Probing Meiotic Recombination and Aneuploidy of Single Sperm Cells by Whole-Genome Sequencing" Science 338: 1627-1630 (2012).
Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie. "Genome Analyses of Single Human Oocytes" Cell 155: 1492-1506 (2013).
Yan, Liying; Huang, Lei; Xu, Liya; Huang, Jin; Ma, Fei; Zhu, Xiaohui; Tang, Yaqiong; Liu, Mingshan; Lian, Ying; Liu, Ping; Li, Rong; Lu, Sijia; Tang, Fuchou; Qiao, Jie; Xie, X Sunney "Live Births after Simultaneous Avoidance of Monogenic Diseases and Chromosome Abnormality by Next-generation Sequencing with Linkage Analyses," Proc Natl Acad Sci USA, 112(52), 15964-15969, (2015).
Chen, Chongyi; Xing, Dong; Tan, Longzhi; Li, Heng; Zhou, Guangyu; Huang, Lei; Xie, X. Sunney "Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI)," Science 356, 189-194 (2017).
COVID-19
Cao, Yunlong; Jian, Fanchong; Wang, Jing; Yu, Yuanling; Song, Weiliang; Yisimayi, Ayijiang; Wang, Jing; An, Ran; Chen, Xiaosu; Zhang, Na; Wang, Yao; Wang, Peng; Zhao, Lijuan; Sun, Haiyan; Yu, Lingling; Yang, Sijie; Xiao, Tianhe; Gu, Qingqing; Shao, Fei; Hao, Xiaohua; Xu, Yanli; Jin, Ronghua; Shen, Zhongyang; Wang, Youchun; Xie, Xiaoliang Sunney "Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution," Nature (2022)
Cao, Yunlong; Jian, Fanchong; Zhang, Zhiying; Yisimayi, Ayijiang; Hao, Xiaohua; Bao, Linlin; Yuan, Fei; Yu, Yuanling; Du, Shuo; Wang, Jing; Xiao, Tianhe; Song, Weiliang; Zhang, Ying; Liu, Pulan; An, Ran; Wang, Peng; Wang, Yao; Yang, Sijie; Niu, Xiao; Zhang, Yuhang; Gu, Qingqing; Shao, Fei; Hu, Yaling; Yin, Weidong; Zheng, Aihua; Wang, Youchun; Qin, Chuan; Jin, Ronghua; Xiao, Junyu; Xie, Xiaoliang Sunney "Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents," Cell Reports (2022)
Cao, Yunlong; Song, Weiliang; Wang, Lei; Liu, Pan; Yue, Can; Jian, Fanchong; Yu, Yuanling; Wang, Yao; Yisimayi, Ayijiang; Wang, Peng; Wang, Yao; Zhu, Qianhui; Deng, Jie; Fu, Wangjun; Yu, Ling; Zhang, Na; Wang, Jing; Xiao, Tianhe; An, Ran; Wang, Jing; Liu, Lu; Yang, Sijie; Niu, Xiao; Gu, Qingqing; Shao, Fei; Hao, Xiaohua; Meng, Bo; Gupta, Ravindra Kumar; Jin, Ronghua; Wang, Youchun; Xie, Xiaoliang Sunney; Wang, Xiangxi "Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75," Cell Host & Microbe 30(11), 1527-1539 (2022)
Jian, Fanchong; Yu, Yuanling; Song, Weiliang; Yisimayi, Ayijiang; Yu, Lingling; Gao, Yuxue; Zhang, Na; Wang, Yao; Shao, Fei; Hao, Xiaohua; Xu, Yanli; Jin, Ronghua; Wang, Youchun; Xie, X. Sunney; Cao, Yunlong "Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants," Lancet Infect Dis (2022)
Cao, Yunlong; Yisimayi, Ayijiang; Jian, Fanchong; Song, Weiliang; Xiao, Tianhe; Wang, Lei; Du, Shuo; Wang, Jing; Wang, Jing; Li, Qianqian; Chen, Xiaosu; Yu, Yuanling; Wang, Peng; Zhang, Zhiying; Liu, Pulan; An, Ran; Hao, Xiaohua; Wang, Yao; Wang, Jing; Feng, Rui; Sun, Haiyan; Zhao, Lijuan; Zhang, Wen; Zhao, Dong; Zheng, Jiang; Yu, Lingling; Li, Can; Zhang, Na; Wang, Rui; Niu, Xiao; Yang, Sijie; Song, Xuetao; Chai, Yangyang; He, Ye; Shi, Yansong; Zheng, Linlin; Li, Zhiqiang; Gu, Qingqing; Shao, Fei; Huang, Weijin; Jin, Ronghua; Shen, Zhongyang; Wang, Youchun; Wang, Xiangxi; Xiao, Junyu; Xie, Xiaoliang Sunney "BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection," Nature 608, 593-602 (2022)
Cao, Yunlong; Hao, Xiaohua; Wang, Xi; Wu, Qianhui; Song, Rui; Zhao, Dong; Song, Weiliang; Wang, Yao; Yisimayi, Ayijiang; Wang, Wei; Zhang, Wen; Du, Juan; Yu, Hongjie; Xie, Xiaoliang Sunney; Jin, Ronghua "Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine," Cell Research 32, 107-109 (2022)
Cao, Yunlong; Wang, Jing; Jian, Fanchong; Xiao, Tianhe; Song, Weiliang; Yasimayi, Ayijiang; Huang, Weijin; Li, Qianqian; Wang, Peng; An, Ran; Wang, Jing; Wang, Yao; Niu, Xiao; Yang, Sijie; Liang, Hui; Sun, Haiyan; Li, Tao; Yu, Yuanling; Cui, Qianqian; Liu, Shuo; Yang, Xiaodong; Du, Shuo; Zhang, Zhiying; Hao, Xiaohua; Shao, Fei; Jin, Ronghua; Wang, Xiangxi; Xiao, Junyu; Wang, Youchun; Xie, Xiaoliang Sunney "Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies," Nature 602, 657-663 (2021)
Du, Shuo; Liu, Pulan; Zhang, Zhiying; Xiao, Tianhe; Yasimayi, Ayijiang; Huang, Weijin; Wang, Youchun; Cao, Yunlong; Xie, Xiaoliang Sunney; Xiao, Junyu "Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants," Cell Research 31, 1130–1133 (2021)
Cao, Yunlong; Yisimayi, Ayijiang; Bai, Yali; Huang, Weijin; Li, Xiaofeng; Zhang, Zhiying; Yuan, Tianjiao; An, Ran; Wang, Jing; Xiao, Tianhe; Du, Shuo; Ma, Wenping; Song, Liyang; Li, Yongzheng; Li, Xiang; Song, Weiliang; Wu, Jiajing; Liu, Shuo; Li, Xuemei; Zhang, Yonghong; Su, Bin; Guo, Xianghua; Wei, Yangyang; Gao, Chuanping; Zhang, Nana; Zhang, Yifei; Dou, Yang; Xu, Xiaoyu; Shi, Rui; Lu, Bai; Jin, Ronghua; Ma, Yingmin; Qin, Chengfeng; Wang, Youchun; Feng, Yingmei; Xiao, Junyu; Xie, Xiaoliang Sunney "Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines," Cell Research 31(7), 732-741 (2021)
Du, Shuo; Cao, Yunlong; Zhu, Qinyu; YU, Pin; Qi, Feifei; Wang, Guopeng; Du, Xiaoxia; Bao, Linlin; Deng, Wei; Zhu, Hua; Liu, Jiangning; Nie, Jianhui; Zheng, Yinghui; Liang, Haoyu; Liu, Ruixue; Gong, Shuran; Liu, Jiangning; Xu, Hua; Yisimayi, Ayijiang; Lv, Qi; Wang, Bo; He, Runsheng; Han, Yunlin; Zhao, Wenjie; Bai, Yali; Qu, Yajin; Gao, Xiang; Ji, Chenggong; Wang, Qisheng; Gao, Ning; Huang, Weijin; Wang, Youchun; Xie, X. Sunney; Su, Xiao-dong; Xiao, Junyu; Qin, Chuan "Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy," Cell 183(4), 1013-1023.e13 (2020)
Cao, Yunlong; Su, Bin; Guo, Xianghua; Sun, Wenjie; Deng, Yongqiang; Bao, Linlin; Zhu, Qinyu; Zhang, Xu; Zheng, Yinghui; Geng, Chenyang; Chai, Xiaoran; He, Runsheng; Li, Xiaofeng; Lv, Qi; Zhu, Hua; Deng, Wei; Xu, Yanfeng; Wang, Yanjun; Qiao, Luxin; Tan, Yafang; Song, Liyang; Wang, Guopeng; Du, Xiaoxia; Gao, Ning; Liu, Jiangning; Xiao, Junyu; Su, Xiaodong; Du, Zongmin; Feng, Yingmei; Qin, Chuan; Qin, Chengfeng; Jin, Ronghua; Xie, X. Sunney "Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells," Cell 182(1), 73-84.e16 (2020) [37]
Key Review Articles
Min, Wei; Freudiger, Christian W.; Lu, Sijia; Xie, X. Sunney. "Coherent Nonlinear Optical Imaging: beyond Fluorescence Microscopy" Annu. Rev. Phys. Chem. 62: 507-530 (2011).
Li, Gene-Wei; Xie, X. Sunney. "Central Dogma at the Single-Molecule Level in Living Cells" Nature 475: 308-315 (2011).
Xie, X. Sunney. "Enzyme Kinetics, Past and Present" Science 342: 1457-1459 (2013).
Xie, X. Sunney. "Single Molecules Meet Genomics: Pinpointing Precision Medicine" JAMA 20: 2021-2 (2015).
Huang Lei; Ma Fei; Chapman Alec; Lu Sijia; Xie X. Sunney. “Single-Cell Whole-Genome Amplification and Sequencing” Annu. Rev. Genomics Hum. Genet. 16: 79-102 (2015).
Cheng, Ji-xin; Xie, X. Sunney. “Vibrational Spectroscopic Imaging of Living Systems: An Emerging Platform for Biology and Medicine” Science 350, aaa8870 (2015). [37]

人才培养

1999年,谢晓亮进入哈佛大学任教来,培养了多名博士和博士后,截止到2017年,他所培养的学生在世界四十多所大学任教,其中一些学生的具体信息如下 [15]
Graduate Students
Srinjan Basu
2006-2012
Cambridge University
Paul Blainey
2001-2007
Assistant Professor, Department of Biological Engineering, MIT, Broad Institute
Long Cai
2001-2006
Assistant Professor of Chemistry, CalTech
Chongyi Chen
2009-2014
Harvard Univerisity, Cambridge, Massachusetts
Huiyi Chen
2006-2011
Nanyang Technological Univerisity, Lee Kong Chian School of Medicine, Singapore
Paul J. Choi
2005-2009
Senior Research Scientist , Genome Institute of Singapore
Shasha Chong
2009-2014
Department of Molecular & Cell Biology, University of California, Berkeley, California
Brian English
2001-2007
Albert Einstein College of Medicine
Conor Evans
2002-2007
Assistant Professor, Harvard Medical School
Christian Freudiger
2007-2011
CTO and Cofounder, Invenio Imaging
Sangjin Kim
2004-2010
Department of Molecular, Cellular & Developmental Biology, Yale University
John Krug
1998-2004
Roche
Gene-Wei Li
2005-2010
University of California, San Francisco
Sijia Lu
2008-2012
CTO and Cofounder, Yikon Genomics, Taizhou, China
Guobin Luo
2000-2006
Life Technologies
Wei Min
2001-2007
Assistant Professor, Columbia University
Xiaolin Nan
2001-2007
Assistant Professor, Oregon Health Science University
Brian Saar
2005-2010
Lincoln Laboratory, Massachusetts Institute of Technology
ErikSánchez
1995-1999
Assistant Professor, Portland State University
Peter Sims
2005-2009
Assistant Professor of Systems Biology, Department of Biochemistry & Molecular Physics, Columbia University Medical Center
Zi Hertz He
2011-2014
Bloomberg L.P., London
Ziqing Winston Zhao
2009-2015
Postdoc, Institute for Molecular and Cell Biology (IMCB), Singapore
Xu Zhang
2010-2015
Postdoctoral Fellow, Harvard University
Wenlong Yang
2011-2017
Postdoctoral Fellow, Harvard University
Postdoctoral Fellows
Dr. David Arnett
1998-1999
Associate Professor, Northwestern College, Iowa
Dr. Lewis Book
2000-2001
Northrop Grumman Space Technology, California
Dr. Erik Brostromer
2010-2011
Dr. Silvia Carrasco
2005-2006
Knowledge and Technology Transfer (KTT) director, ICFO
Dr. Huiyi Chen
2011-2012
Nanyang Technological Univerisity, Lee Kong Chian School of Medicine, Singapore
Dr. Peng Chen
2004-2005
Peter Debye Professor of Chemistry, Cornell University, Deptartment of Chemistry and Chemical Biology
Dr. Ji-Xin Cheng
2000-2003
Professor, Purdue University, Weldon School of Biomedical Engineering
Dr. James Chesko
1997
Novartis Vaccines and Diagnostics, Emeryville, California
Dr. Jonathan Choi
1999-2000
Dr. Paul J. Choi
2009-2010
Senior Research Scientist , Genome Institute of Singapore
Dr. Robert A. Crowell
1994-1995
Brookhaven National Laboratory
Dr. Haifeng Duan
2009-2011
Biodynamic Optical Imaging Center (BIOPIC), Peking University, China
Dr. Xiaojie Duan
2007-2008
Assistant Professor, Peking University
Dr. Robert C. Dunn
1992-1995
Professor of Chemistry, University of Kansas
Dr. Johan Elf
2005-2007
Associate Professor in Molecular Biotechnology, University of Uppsala, Sweden
Dr. Wagner Faustino
2008-2010
Adjunct Professor, Federal University of Paraiba, Brazil
Dr. Kevin Fiala
2007-2009
MIT, Office of Technology Development
Dr. Christian Freudiger
2011-2013
CTO and Cofounder, Invenio Imaging
Dr. Nir Friedman
2003-2007
Weizmann Institute, Israel
Dr. Marcel Friedrich
2007-2008
Siemens Management Consulting, Munich, Germany
Dr. Feruz Ganikhanov
2004-2006
Assistant Professor, West Virginia University
Dr. Christof Gebhardt
2010-2013
Deputy Head, Institute of Biophysics, Ulm University, Germany
Dr. William Greenleaf
2008-2011
Assistant Professor, Genetics Dept., Stanford University School of Medicine
Dr. Terumasa Ito
2011-2012
Sony Coporation Research & Development
Dr. Minbiao Ji
2011-2014
Professor, Department of Physics, Fudan University, Shanghai, China
Dr. Lingjie Kong
2012-2013
Janelia Farm Research Campus, Virginia
Dr. Kang Taek Lee
2003-2004
Assistant Professor, Department of Chemistry, Gwangju Institute of Science and Technology (GIST), Korea
Dr. Nam Ki Lee
2006-2009
Assistant Professor, Pohang University of Science and Technology, S. Korea
Dr. Gene-Wei Li
2010
UCSF
Dr. Jeff Li
2002-2008
Massachusetts Institute of Technology
Dr. Giuseppe Lia
2006-2009
CNRS, Centre de Genetique Moleculaire, Paris
Dr. Hong Peter Lu
1995-1999
Professor, Ohio Eminent Scholar, Bowling Green State University
Dr. Guobin Luo
2006-2008
Life Technologies
Dr. Yuntao Steve Mao
2011-2012
Scientific Editor, Cell, Cell Press, Cambridge
Dr. Wei Min
2008-2010
Assistant Professor, Columbia University, Department of Chemistry
Dr. Lukas Novotny
1996-1999
Professor, ETH Zürich
Dr. Antoine van Oijen
2001-2004
Professor, University of Wollongong, Australia
Dr. Pavel Pospisil
2001-2002
Palacky University, Czech Republic, Department of Experimental Physics
Dr. Eric Potma
2001-2005
Associate Professor, University of California at Irvine, Department of Chemistry
Dr. Maarten Roeffaers
2009-2010
Assistant Professor, Katholieke Universiteit Leuven
Dr. Rahul Roy
2007-2012
Assistant Professor, Indian Institute of Science, Department of Chemical Engineering, Bangalore, India
Dr. Markus Rueckel
2007-2008
BASF, Germany
Dr. Erik Sánchez
1999-2002
Assistant Professor of Physics, Portland State University
Dr. Ahbijit Sarkar
2002-2003
Assistant Professor, Dept. of Chemistry & Physics, Virginia State University
Dr. Charles Schroeder
2004-2007
Assistant Professor, University of Illinois, Urbana-Champaign, Department of Biomolecular Engineering
Dr. Katsuyuki Shiroguchi
2009-2012
Laboratory Leader, RIKEN Research Center for Allergy & Immunology, Laboratory for Integrative Genomics
Dr. Peter Sims
2009-2011
Assistant Professor of Systems Biology, Department of Biochemistry & Molecular Physics, Columbia University Medical Center
Dr. Hongye Sun
2000-2002
Vice President of Operation and Technology Platform, Chief Operating Officer, WuXi Genomic Center, WuXi AppTec, Shanghai
Dr. David Suter
2011-2013
Assistant Professor, School of Life Sciences, EPFL, Switzerland
Dr. Yuichi Taniguchi
2006-2011
Unit Leader, Quantitative Biology Center, RIKEN, Japan
Dr. Andreas Volkmer
1999-2001
University of Stuttgart, Germany, Institute of Physics
Dr. David Ward
2005-2007
President and Chairman, Piffany, Inc.
Dr. Jie Xiao
2002-2006
Assistant Professor, Johns Hopkins University School of Medicine, Department of Biophysics and Biophysical Chemistry
Dr. Haw Yang
2000-2002
Associate Professor of Chemistry, Princeton University
Dr. Wei Yuan Yang
2005-2007
Researcher, Academia Sinica, Taiwan, Institute of Biological Chemistry
Dr. Jun Yong
2011-2013
Biodynamic Optical Imaging Center (BIOPIC), Peking University, China
Dr. Ji Yu
2002-2006
Assistant Professor of Genetics and Developmental Biology, University of Connecticut Health Center
Dr. Guoqing Zhang
2010-2011
Assistant Professor, University of Science and Technology of China, School of Chemistry and Materials Science
Dr. Chenghang Zong
2009-2013
Assistant Professor, Department of Molecular and Human Genetics. Baylor College of Medicine
Dr. Andreas Zumbusch
1997-1999
Professor of Physical Chemistry, Universität Konstanz, Germany
Dr. Yan Gu
2013-2014
Scientist at Bristol-Myers Squibb
Dr. Dan Fu
2010-2015
Assistant Professor, Department of Chemistry, University of Washington
Dr. Xiaohui Ni
2011-2015
Cynvenio Biosystems, California
Dr. Yi Yin
2015-2016
Postdoc, University of Washington
Dr. Haisong Liu
2014-2016
Postdoctoral Fellow, Salk Institute
Dr. Asaf Tal
2015-2017
Dr. Fa-Ke Frank Lu
2011-2017
Assistant Professor, Department of Biomedical Engineering, Binghamton University, State University of New York
Dr. Sabin Mulepati
2014-2017
Intellia Therapeutics, Massachusetts
Visiting Scholars
Prof. Jianming Li
2011
Southern Medical University, China
Prof. Biman Bagchi
2007
Indian Institute of Science
Prof. Paul Champion
2002-2003
Department of Physics, Northeastern University
Prof. Binny Cherayil
2004-2005
Department of Inorganic and Physical Chemistry, Indian Institute of Science
Prof. Nai-Ho Cheung
2000-2001
Department of Physics, Hong Kong Baptist University
Dr. Peijun Cong
2010
Invenio Imaging
Dr. Mircea Cotlet
2003
Brookhaven National Laboratory, Center for Functional Nanomaterials
Prof. Hao Ge
2010-2011
Biodynamic Optical Imaging Center (BIOPIC), Peking University, China
Prof. Casey Hynes
2011
Department of Molecular Biophysics, University of Colorado, Boulder
Prof. Carey Johnson
1997
Department of Chemistry, University of Kansas
Dr. Laura Kaufman
2002-2004
Department of Chemistry, Columbia University
Dr. Francois Legare
2004-2006
INRS-EMT, Université du Québec, Varennes, Canada
Prof. Peter Leung
1995
Department of Physics, Portland State University
Prof. Yuanzong Li
2002-2003
College of Chemistry and Molecular Engineering, Peking University, China
Prof. Vahid Sandoghdar
2009
Department of Chemistry, Swiss Federal Institute of Technology, Switzerland
Prof. Andrei Tokmakoff
2005-2006
Department of Chemistry, Massachusetts Institute of Technology
Dr. Martin Vogel
2006-2008
Max Planck Institute of Biophysics, Department of Molecular Neurogenetics
Prof. Nils Walter
2006
Department of Chemistry, University of Michigan
Prof. Xinhua Wan
2004-2005
College of Chemistry and Molecular Engineering, Peking University, China
Prof. Peng-Ye Wang
2010
Institute of Physics, Chinese Academy of Sciences
Prof. Luying Xun
2004-2005
School of Molecular Biosciences, Washington State University
Prof. Xinsheng Zhao
2003
College of Chemistry and Molecular Engineering, Peking University, China
Prof. Zemin Yao
2014-2015
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Canada
Yuanzhen Suo
2015-2017
Shanghai Jiao Tong University
Shufang Wang
2016-2017
Chinese PLA General Hospital

荣誉表彰

时间
奖项/荣誉
授予单位
2024年12月
2024腾冲科学大奖
2024腾冲科学家论坛 
2021年度
北京市科学技术奖突出贡献中关村奖
北京市人民政府 
2017年12月
2017年度中国留学人员50人榜单
2017年11月
中国科学院外籍院士
中国科学院 
2017年9月
求是杰出科学家奖
香港求是基金会
2016年10月
美国国家医学院院士
美国国家医学院 
2016年
吴瑞奖
华人生物学家协会
2015年
贝时璋奖
中国生物物理学会
2015年
阿尔伯尼生物医学奖(Albany)
纽约州阿尔巴尼医学中心
2015年
Peter Debye物理化学奖
美国化学会
2014年
美国光学会会士
美国光学会
2014年
德国洪堡学者
2013年
美国NIH Director's Pioneer Award
2013年
Ellis R. Lippincott奖
美国光学学会及应用光谱学会
2012年
Harrison Howe奖
美国化学会Rochester分部
2012年
美国微生物学会会士
美国微生物学会
2012年
Founders奖
美国生物物理学会
2011年5月3日
美国国家科学院院士
美国国家科学院 
2010年
中国化学会荣誉会士
中国化学会
2009年
欧内斯特·奥兰多·劳伦斯奖(化学类)
美国能源部
2008年
美国物理学会会士
美国物理学会
2008年
美国艺术与科学学院院士
美国艺术与科学学院 
2008年
Berthold Leibinger Zukunftspreis激光技术奖
2007年
Willis E.Lamb激光科学与量子光学奖
2006年
美国科学促进会会士
美国科学促进会
2006年
美国生物物理学会会士
美国生物物理学会
2004年
美国NIH Director's Pioneer Award
2003年
以色列Raymond and Beverly Sackler 物理科学奖
2003年
Hoope奖
哈佛大学
2003年
Joe Markson优秀本科毕业论文指导教师
1996年
Coblentz奖

社会任职

播报

编辑
任职时间
担任职务
2023年
第十四届全国政协委员、常委、教科卫体委员会委员 
2009年—2011年
《科学(Science)》编委
2004年—
国家纳米科学中心学术委员会委员(第一届、第二届)
2002年—2007年
《物理化学年度评论(Annual Review of Physical Chemistry)》编委
2001年—2006年
《化学研究述评(Accounts of Chemical Research)》编委
2001年—2009年
中国科学院化学研究所分子动态与稳态结构国家重点实验室学术委员会委员(第五届)
2001年—
《化学物理(Chemical Physics)》编委
2001年—
《化学物理学报(Chemical Physics Letters)》编委
2000年—
《化学物理化学(Chem. Phys. Chem.)》编委
2000年—2008年
《物理化学杂志(Journal of Physical Chemistry )》编委
2000年—2001年
《生物物理学杂志(Biophysical Journal)》编委
1999年—2007年
《显微镜技术杂志(Journal Of Microscopy)》编委
1999年—2002年
《单分子(Single Molecules)》编委
第十四届北京市政协委员 
物理化学学报》编委 

个人生活

  • 家世背景
谢晓亮的父亲谢有畅与母亲杨骏英皆为北京大学化学系的教授

人物评价

谢晓亮在非线性拉曼显微学和高灵敏度分子振动成像领域具有创新研究,在创立单分子生物物理化学领域中处于科学领导地位,而且他在酶反应动力学和活细胞基因表达领域做出了杰出工作 (2009年美国欧内斯特·奥兰多·劳伦斯奖)
谢晓亮是单细胞生物学领域的领军人物,他已在该领域做出了关于单个分子及其行为影响细胞的生命过程乃至人类疾病的诸多研究成果(2015年美国阿尔伯尼生物医学奖)
谢晓亮是学科交叉研究的践行者,从物理化学、生物物理到生物化学,再到分子生物学,基因组学及临床医学,他无畏探索,不断创新,他是单分子酶学的创始人、单分子生物物理化学的奠基人之一、相干拉曼散射显微成像技术和单细胞基因组学的开拓者,在单分子生物物理和生物医学光学成像领域作出了杰出的贡献 (2017年求是科学基金会评)
做事情就是要持之以恒,不要放弃,要坚持,要不怕困难的做下去,要有耐心,不要追求那种短期就能出成果的东西。谢晓亮常常会用4年甚至更长的时间来做一个研究,他发现自己做错的东西,也不放弃,重新开始做,所以,坚持是一个很重要的东西,是他获得成功肯定的一个很重要的元素,对我也意义重大 (美国国家科学院院士、哈佛大学教授庄小威
谢晓亮的第一个基础研究工作是1998年开展的单分子酶学,他开创了在单分子层面对生命过程的研究。近年他又开始探探索在医学上的应用。中国引进现代医学后,在现代药学方面只有少数几个药物作用领域的发现,在现代医学技术上唯一的发明和应用就是谢晓亮和汤富酬、乔杰三个团队合作诞生的‘MALBAC婴儿’ (北京大学生命科学院饶毅
谢晓亮的MALBAC技术能够改变整个生物医学,其对未来精准医学的发展和应用的贡献是不可限量的。“获得终身教授的人很多,但真正能够在人类历史上,特别是科技史上留下印记的科学家非常少见,而谢晓亮将理论和技术结合,用技术解决科学问题,是引领整个科学界发展的真正的一流科学家,他是一个让你无法预知将来还会做出什么创造性工作的科学家。这是一个科学家具有潜在创造力、影响力、引领力的标志 (中国医学科学院院长曹雪涛

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